Modification of Cell Surfaces by Enzymatic Introduction of Special Sialic Acid Analogues
Identifieur interne : 001341 ( Main/Exploration ); précédent : 001340; suivant : 001342Modification of Cell Surfaces by Enzymatic Introduction of Special Sialic Acid Analogues
Auteurs : R. E. Kosa [Allemagne] ; H. J. Gross [Allemagne]Source :
- Biochemical and Biophysical Research Communications [ 0006-291X ] ; 1993.
Abstract
Abstract: Taking advantage of the defined acceptor specifity of rat liver α2,6-sialyltransferase, N-linked Ga1β1,4GlcNAc-sequences of glycoconjugates at the plasma membrane of viable human erythrorytes and lymphoblastic IN-9 cells were modified to terminate in three NeuAc analogues endowed with special bemchemical properties: sialidase-resistant 9-amino-NeuAc, O-acetylesterase-resistant 9-acetamido-NeuAc and photolabile 9-azido-NeuAc. Incorporation of the latter analogues and of parent NeuAc proceeded to similar values, whereas 9-amino-NeuAc yielded slightly reduced values.
Url:
DOI: 10.1006/bbrc.1993.1136
Affiliations:
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